Understanding Wegovy and Its Mechanism
Wegovy (semaglutide) is a prescription medication approved by the FDA in June 2021 for chronic weight management in adults. As a higher-dose version of the diabetes drug Ozempic, it works by mimicking glucagon-like peptide-1 (GLP-1), a natural hormone that regulates appetite and food intake.
How It Works
Wegovy functions through multiple mechanisms:
- Reduces hunger signals
- Increases feelings of fullness
- Slows gastric emptying
- Helps regulate blood sugar levels
- Influences brain's appetite control centers
Clinical Evidence and Effectiveness
The STEP (Semaglutide Treatment Effect in People with Obesity) clinical trials demonstrated impressive results:
- Average weight loss of 15-17% over 68 weeks
- Significant improvements in cardiovascular risk factors
- Better glycemic control in patients with type 2 diabetes
- Enhanced quality of life and physical function
Who Can Benefit?
Wegovy is intended for adults with:
- BMI of 30 or greater (obesity)
- BMI of 27 or greater (overweight) with at least one weight-related condition
Maximizing Success with Wegovy
Lifestyle Components
To achieve optimal results, patients should combine Wegovy with:
- Caloric deficit of 500-750 calories daily
- Regular physical activity (150+ minutes weekly)
- Adequate sleep (7-9 hours nightly)
- Stress management techniques
"Wegovy is not a magic solution – it's a tool that works best when combined with proper nutrition and lifestyle changes." - Dr. Robert Kushner, obesity medicine specialist
Cost and Accessibility
| Duration | Approximate Cost (Without Insurance) |
|---|---|
| Monthly | $1,300-$1,500 |
| Annually | $15,600-$18,000 |
Side Effects and Considerations
Common side effects include:
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Abdominal pain
Important Precautions
Before starting Wegovy, individuals should:
- Discuss any pre-existing conditions with a healthcare provider
- Inform the doctor about other medications
- Note that it's not recommended during pregnancy or breastfeeding
Long-Term Maintenance
Research indicates that continued use may be necessary for sustained results. When treatment is discontinued, patients may experience:
- Gradual weight regain
- Return of previous appetite levels
- Changes in eating behaviors
Special Populations
Different results may be observed in:
- Elderly patients
- Those with diabetes
- Individuals with certain gastrointestinal conditions
- Patients with a history of pancreatitis
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