Understanding Tadalafil
Tadalafil, commonly known by its brand name Cialis, is a medication primarily used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension. It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors, which work by increasing blood flow to certain areas of the body.
For more detailed information on how tadalafil works, visit Mayo Clinic's page on Tadalafil.
Duration and Onset of Action
Onset
Tadalafil typically begins working within 30-60 minutes after ingestion. However, consuming a high-fat meal beforehand may delay its absorption and onset of action.
Duration of Effects
One of tadalafil's distinguishing features is its extended duration of action, lasting up to 36 hours - significantly longer than other ED medications like sildenafil (Viagra) or vardenafil (Levitra). This extended window has earned it the nickname "the weekend pill."
Factors Influencing Duration
Several factors can affect how long tadalafil's effects last:
- Age
- Metabolism rate
- Kidney and liver function
- Dosage
- Other medications
- Food intake
- Overall health status
- Severity of ED
- Underlying conditions
Different Formulations
Daily Tadalafil
For those prescribed daily tadalafil (2.5mg or 5mg):
The continuous presence of the medication in your system means you're ready for sexual activity at any time, without planning ahead.
As-Needed Dosing
Higher doses (10mg or 20mg) are prescribed for as-needed use, with effects lasting up to 36 hours.
Side Effects and Duration
Common side effects typically resolve within 24-48 hours:
| Side Effect | Typical Duration |
|---|---|
| Headache | 12-24 hours |
| Back pain | 24-48 hours |
| Muscle aches | 24-48 hours |
| Indigestion | Variable |
| Flushing | Variable |
| Nasal congestion | Variable |
Tips for Optimal Use
- Take on an empty stomach or after a light meal
- Maintain consistent timing
- Avoid excessive alcohol consumption
- Stay hydrated
- Follow prescribed dosage
- Be patient - it may take a few tries to see full benefits
- Consult your doctor if experiencing adverse effects
Important Safety Considerations
Drug Interactions
Tadalafil can interact with various medications, particularly:
- Nitrates
- Alpha-blockers
- Certain antifungal medications
- Some antibiotics
Medical Emergency
Seek immediate medical attention if you experience:
- Erection lasting longer than 4 hours (priapism)
- Sudden vision loss
- Hearing problems
- Severe dizziness
- Chest pain
For more information on side effects, visit WebMD's Tadalafil Side Effects or Drugs.com's Tadalafil Interactions.
Storage and Handling
To maintain optimal effectiveness:
- Store at room temperature
- Keep away from moisture
- Protect from direct sunlight
- Keep out of reach of children