Recommended Dosage of Tadalafil for Erectile Dysfunction

Understanding Tadalafil and Erectile Dysfunction

Tadalafil, commonly known by its brand name Cialis, is a medication used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension. It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors, which work by inhibiting the enzyme PDE5 to increase blood flow to the penis during sexual arousal.

How Tadalafil Works

Tadalafil works by relaxing blood vessels in the penis, allowing for increased blood flow when sexually aroused. This process is essential for achieving and maintaining an erection sufficient for sexual activity.

Recommended Dosage Options

Daily Dosing

For patients who prefer daily medication:

Starting dose: 2.5mg once daily
May be increased to 5mg based on effectiveness and tolerability
Take at approximately the same time each day
No timing restrictions relative to sexual activity

As-Needed Dosing

For occasional use:

Initial dose: 10mg taken prior to anticipated sexual activity
Maximum dose: 20mg if needed
Take at least 30 minutes before sexual activity
Effects can last up to 36 hours

Factors Affecting Dosage

Several considerations influence the appropriate dosage:

Age
Kidney function
Liver function
Other medications
Overall health status

Special Populations

Creatinine Clearance     Recommended Dose
30-50 mL/min            Maximum 5mg daily
<30 mL/min              Maximum 2.5mg daily

Important Considerations

Never exceed one dose per day, regardless of dosing regimen chosen.

Timing and Usage Tips

Can be taken with or without food
Limit alcohol consumption
Allow sufficient time before sexual activity
For daily dosing, maintain consistent timing

Drug Interactions

Tadalafil can interact with:

Nitrates for chest pain
Alpha blockers
Antifungal medications
HIV protease inhibitors
Other ED medications

Side Effects

Common side effects include:

Headache
Indigestion
Back pain
Muscle aches
Flushing
Nasal congestion

Emergency Situations

Seek immediate medical attention if experiencing:

Vision changes
Hearing problems
Prolonged erection (>4 hours)
Chest pain

Medical Precautions

Before taking tadalafil, inform your healthcare provider if you have:

Heart disease
High or low blood pressure
Liver or kidney disease
A history of stroke

For more detailed information, visit resources like the Mayo Clinic, Drugs.com, or the FDA medication guide.