What are the most severe side effects of Dupixent?

## Understanding Dupixent: A Brief Overview Dupixent (dupilumab) is a monoclonal antibody used to treat various chronic inflammatory conditions such as atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis. It works by inhibiting the signaling of interleukin-4 and interleukin-13, which are key drivers of inflammation in these conditions. ## Most Severe Side Effects 🚨 ### 1. Allergic Reactions Severe hypersensitivity reactions can occur, including: 1. Anaphylaxis 2. Serum sickness 3. Angioedema 4. Generalized urticaria Symptoms may include: - Hives - Difficulty breathing - Swelling of the face, lips, tongue, or throat ### 2. Eye-Related Complications * **Conjunctivitis** (pink eye) * **Keratitis** (inflammation of cornea) * **Uveitis** (inflammation of the uvea) * Severe eye pain or vision changes * Eye dryness and irritation > "Patients experiencing persistent eye symptoms should seek immediate medical attention" - [American Academy of Ophthalmology](https://www.aao.org/) ### 3. Blood and Immune System Disorders * **Eosinophilia** - elevated levels of certain white blood cells * Potential for vasculitis in rare cases * Eosinophilic pneumonia * Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) ### 4. Parasitic (Helminth) Infections Patients with known helminth infections should receive treatment before starting Dupixent. The medication may reduce immunity to parasitic infections. ## Monitoring and Management ### Required Monitoring 1. Regular eye examinations 2. Blood work to monitor eosinophil levels 3. Skin condition assessment 4. Vaccination status review ### Risk Reduction Strategies 1. Follow proper injection technique 2. Maintain regular medical check-ups 3. Report early symptoms promptly 4. Adhere to prescribed dosing schedule ## When to Seek Emergency Care 🏥 Immediate medical attention is required for: * Difficulty breathing * Severe dizziness * Facial/throat swelling * Severe eye pain or vision changes * High fever ### Documentation and Reporting Keep detailed records of: * Side effect onset * Severity * Duration * Associated symptoms Report serious side effects to: * Your healthcare provider * [FDA MedWatch](https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program) ## Special Considerations ### Vaccination Timing Live vaccines should be avoided or administered before starting treatment. [CDC Vaccination Guidelines](https://www.cdc.gov/vaccines/index.html) ### Pregnancy and Breastfeeding Limited data available; consult healthcare provider for risk assessment. For more detailed information, visit the [official Dupixent website](https://www.dupixent.com/) or consult resources like the [FDA's medication guide](https://www.fda.gov/drugs/drug-safety-and-availability) for the latest updates and safety information.

What are the most severe side effects of Dupixent?

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