What to Expect During Your First Week on Wegovy

## Understanding Wegovy Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA in June 2021. It works by mimicking a hormone that targets areas of the brain involved in regulating appetite and food intake, helping you feel fuller and more satisfied with smaller meals. For more detailed information, visit the [FDA's official page on Wegovy](https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss). ## Initial Dosing and Preparation Your healthcare provider will start you on the lowest dose (0.25mg) to help your body adjust. This "initiation dose" is significantly lower than the eventual target dose of 2.4mg. Before starting: - **Consult with Your Healthcare Provider**: Discuss pre-existing conditions and current medications - **Understand the Injection Process**: Learn proper self-administration techniques - **Set Realistic Expectations**: Combine medication with healthy diet and exercise ### Injection Tips * Choose the same day each week for consistency * Rotate injection sites between abdomen, thigh, or upper arm * Clean the injection site with alcohol before administering * Store pens in the refrigerator between 36°F to 46°F (2°C to 8°C) ## Common Side Effects During the first few days, you might experience: 1. Nausea (most common) 2. Digestive changes 3. Fatigue 4. Headache 5. Injection site reactions > **Important:** Most side effects are mild to moderate and typically improve over time. Contact your healthcare provider if side effects become severe or concerning. For more information on potential side effects, check out the [Mayo Clinic's overview of semaglutide](https://www.mayoclinic.org/drugs-supplements/semaglutide-subcutaneous-route/side-effects/drg-20478854). ## Dietary and Lifestyle Considerations ### Recommended Approach * Eat smaller portions * Choose protein-rich foods * Stay well-hydrated * Avoid fatty or greasy foods initially * Consider keeping a food diary Focus on consuming a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats. Regular physical activity can enhance your results. ## Monitoring Progress ### What to Track * Weight * Side effects * Appetite changes * Energy levels * Mood ## Support System and Resources - Join online communities like [r/Wegovy](https://www.ema.europa.eu/en/documents/product-information/wegovy-epar-product-information_en.pdf) - Inform close family members - Consider connecting with a dietitian - Keep regular contact with your healthcare provider - Visit websites like [Drugs.com](https://www.drugs.com/wegovy.html) for comprehensive information ## When to Seek Medical Attention Contact your healthcare provider if you experience: * Severe stomach pain * Persistent vomiting * Signs of allergic reaction * Unusual fatigue * Vision changes --- *Remember: This medication works best when combined with lifestyle modifications, including a reduced-calorie diet and increased physical activity.*

What to Expect During Your First Week on Wegovy

Related articles